1. The diagnostic conversation, diagnosis and prognosis of Parkinson's disease Making the diagnosis James Parkinson and the shaking palsy Jean Charcot and better examinations Checking diagnostic accuracy Specificity and sensitivity Prognosis The Hoehn and Yahr scale The unified Parkinson's disease rating scale 2. Pathology of Parkinson's disease What part of the brain fails in Parkinson's disease? Nerve cell connections Chemical pathology of Parkinson's disease 3. Is there an epidemic of Parkinson's disease? Epidemiology of Parkinson's disease John Snow, the father of epidemiology Koch's postulates Investigating clusters of Parkinson's disease Kuru and Creutzfeldt-Jakob disease Does smoking cause Parkinson's disease? Causation versus association, the Hill criteria Epidemiology of smoking and Parkinson's disease Pesticides, head trauma, and Parkinson's disease Parkinson's at the manor

4. Causes of Parkinson's disease Does an infection cause Parkinson's disease? When prophecy fails Do toxins cause Parkinson's disease? : an answer from the frozen addicts Do genes cause Parkinson's disease? All disease is genetic disease 5. Medications for Parkinson's disease The herbal tradition Herbal treatment of Parkinson's disease Awakenings, L-Dopa therapy Dopamine and schizophrenia, the dopamine receptor Rational drug therapy, trying to prevent progression of Parkinson's disease Coenzyme Q₁₀, another quest for neuroprotection The challenges of taking L-dopa 6. Images of the brain, a picture of the brain is worth a thousand words Imaging and diagnosis Imaging and presymptomatic diagnosis Imaging and disease progression

7. A better model of Parkinson's disease

Dopamine nerve cells connect to many parts of the brain

Dopamine is one of many neurotransmitters that are important in Parkinson's disease

Patients with Parkinson's disease lose cells from many areas of the brain

8. Brain surgery for Parkinson's disease

Can destroying part of the brain be good?

"Brain transplantation," implanting new brain cells

Gene therapy

9. Living with Parkinson's disease

Mood, behavior, and Parkinson's disease

Can L-Dopa make people gamble?

Are Parkinson's disease and Alzheimer's disease related?

Sleep and Parkinson's disease

Fall and injury prevention

10. Conclusions

What happens to brain cells to cause Parkinson's disease?

Living better with Parkinson's disease

The story of Parkinson's disease is not finished

Appendix. Reading about Parkinson's disease

Glossary.